Blar i forfatter "Brovold, Henrik"
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Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men
Brovold, Henrik; Lund, Trine; Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Ytrehus, Kirsti; Zykova, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-19)Several epidemiological studies have pointed at serum uric acid (SUA) as an independent risk factor for mortality, diabetes, hypertension, cardiovascular and kidney disease; however, no clear pathogenic pathway is established. Uric acid (UA) crystals show pro-inflammatory properties and can thus create or contribute to the state of chronic low-grade inflammation, a widely accepted pathogenic mechanism ... -
The use of xanthine oxidoreductase inhibitors in slowing the progression of renal and cardiovascular disease. A summary of available clinical trials
Brovold, Henrik (Master thesis; Mastergradsoppgave, 2016-05-31)There is conflicting evidence whether elevated SUA is associated with or causes cardiovascular and renal disease. Identifying trials using xanthine oxidoreductase (XOR) inhibitors to reduce SUA might provide information on the epidemiological link between SUA and cardiovascular and renal disease. The main objective is to provide a qualitative analysis of the available trials that studied the ...